臺北醫學大學 臺北神經醫學中心 校級神經醫學研究中心

北醫神經婦幼團隊

北醫神經婦幼團隊由公衛學院陳怡樺院長帶領，結合了公衛精神流行病學與環境科學專家、婦產小兒神經與早療臨床醫師組成專業團隊，因應當前少子化危機，關注嬰幼兒發展能否順應環境的巨大變動，並經由長期追蹤探討環境對於孩童身心健康的影響。本團隊自2009年積極投入此議題，並共同為嬰幼兒成長與健康努力，同時關注父母親的整體身心狀態，認為家庭整體健康為社區、群體乃至於國家未來發展之重要關鍵。

本團隊在當前以科技導入健康之重要契機，持續擴充大型「臺灣孕產期健康追蹤研究」長期追蹤資料庫優勢，最大特色莫過於納入影響幼兒發展舉足輕重卻少有文獻支持之議題，包括睡眠、多媒體使用、飲食習慣、室內室外空氣污染與重金屬暴露等之危害。過去研究對象大多集中於3-12歲的兒童，並已指出危害與風險，然針對1-3歲幼兒關鍵期的研究明顯不足，且鮮少能對嬰幼兒以長期追蹤研究整合探討各因子連動與交互作用，及其對幼兒認知語言發展之權重影響力，因此本團隊之特色為利用長期追蹤資料結合家訪採樣調查、收集親子之睡眠品質與體內重金屬含量、家戶環境與空氣品質採樣以及幼兒語言發展與腦部神經發展狀況，再經由人工智慧多模態資訊平台，建立幼兒神經發展預測模型，並有助於醫事人員選取適當的早療決策，進而達到預防醫學與精準公衛之願景。

發表文章

• 1. Su, Y.-Y., Chen, C.-J., Chen, M.-H., Lin, C.-C., Chiou, H.-Y., Hsieh, W.-S., Chang, H., Chen, C.-M., & Chen, P.-C. (2026). Optimizing maternal weight gain to improve neonatal health: A nationwide birth cohort analysis in Taiwan. Journal of the Formosan Medical Association.
• 2. Kuo, C.-Y., Chang, H., Su, E. C.-Y., Huang, Y.-J., Tsai, M.-L., & Tseng, S.-H. (2026). Effectiveness of early intervention and prediction of outcomes in Taiwanese children with developmental delay. Pediatrics and Neonatology, 67(1), 63-69.
• 3. Lee, P.-J., Lo, Y.-C., Chen, Y.-Y., Hu, C.-J., Lin, Y.-K., Pham, Q. T. T., Sim, N. K., Then, C. K., & Shen, S.-C. (2026). Short-chain fatty acids improve hippocampal atrophy, ventricular dilatation and cognitive function decline in aged mice. Aging and Disease, 17(3), 1737-1754.
• 4. Kao, C.-S., Jiang, C.-B., Yang, C.-C., Wang, Y.-L., Chen, Y.-H., Chao, H.-J., Hsi, H.-C., & Chien, L.-C. (2026). Combined exposure to microplastics and cadmium alters gut microbiota composition in preschool children: A cross-sectional study. Journal of Hazardous Materials, 501.
• 5. Li Lin, C.-Y., Huang, Y.-J., Lin, H.-C., Tsai, M.-L., Ku, J.-T., Lee, F.-C., & Chang, H. (2026). Increased incidence of attention-deficit/hyperactivity disorder is associated with early and prolonged exposure to antibiotics: A population-based retrospective cohort study. Pediatrics and Neonatology, 67(1), 45-50.
• 6. Tsai, P.-L., Lo, Y.-C., Tsai, Y.-S., Hwang, Y.-S., Lin, T.-C., Liang, Y.-W., Huang, C.-E., Hsu, F.-C., Tu, Y.-F., & Chen, Y.-Y. (2026). Tract integrity predicts neurological outcomes in neonatal hypoxic-ischemic encephalopathy. Pediatrics and Neonatology, 67(1), 56-62.
• 7. Wong, P.-Y., Su, H.-J., Chao, H.-J., Pan, W.-C., Tsai, H.-J., Yao, T.-C., Liu, W.-Y., Lung, S.-C. C., Adamkiewicz, G., & Wu, C.-D. (2026). An innovative Geo-AI approach in estimating high-resolution urban ambient fungal spore variations. Earth Systems and Environment, 10(1), 31-44.
• 8. Su, Y.-Y., Chen, C.-J., Chen, M.-H., Lin, C.-C., Chan, C.-K., Hsieh, W.-S., Chang, H., Chen, C.-M., Lin, H.-C., & Chen, P.-C. (2026). Atopic diseases in pediatric population: Prematurity and small for gestational age. BMC Pediatrics, 26(1).
• 9. Kao, C.-S., Wang, Y.-L., Jiang, C.-B., Chuang, Y.-C., Chen, Y.-H., Chao, H.-J., Lin, P.-H., Hsi, H.-C., & Chien, L.-C. (2026). A risk-benefit assessment of dietary selenium and its implications in preschool children's growth performance in Taiwan. Environmental Health and Preventive Medicine, 31.
• 10. Chu, C.-Y., Chen, Z.-H., Liang, C.-W., Wu, P.-W., Guo, W.-Q., Chen, B.-W., Huang, C.-C., Li, S.-J., Chang, C.-W., Liang, Y.-W., Kan, S.-A., Lo, Y.-C., Huang, W.-C., Chen, Y.-Y., Chen, S.-Y. (2026). A closed-loop-capable neural interface platform for deep brain modulation via integrated non-viral gene delivery, NIR optogenetics, and electrophysiological recording. Advanced Science, 13(7).
• 11. Chakranon, P., Huang, J.-P., Au, H.-K., Chiou, H., Lin, C.-L., Chen, Y.-Y., Mao, S.-P., Kim, P., Hsu, H.-W., & Chen, Y.-H. (2026). Bidirectional associations between smart device use and body mass index among children aged 3 to 5 years: A longitudinal study. International Journal of Behavioral Nutrition and Physical Activity, 23(1).
• 12. Sun, Y.-H., Tseng, S.-H., Hou, W.-H., Chen, H.-C., Lin, C.-W., & Wang, Y.-H. (2026). Impact of extended reality interventions on core deficits and functional performance among individuals with autism spectrum disorder: A systematic review and meta-analysis. European Child and Adolescent Psychiatry, 35(2), 321-339.
• 13. Chang, C.-C., Chien, L.-C., Hsi, H.-C., & Hseu, Z.-Y. (2026). Evaluating in vitro bioaccessible fractions of rare earth elements in soils by using a simplified bioaccessibility extraction test. Environmental Geochemistry and Health, 48(9).
• 14. Chao, W.-C., Zou, M.-L., Wu, C.-D., Huang, J.-P., Au, H.-K., Lin, C.-L., Mao, S.-P., Chao, H.-J., Chien, L.-C., Hsu, H.-W., Kim, P., & Chen, Y.-H. (2026). Prenatal and postpartum residential greenness and behavioral development in early childhood: Findings from a birth cohort. Environmental Research, 295.
• 15. Hung, S., & Chang, H. (2026). Recurrent hypersomnia following infections: A Kleine–Levin syndrome–like presentation with thalamic hypoperfusion. Psychiatry and Clinical Neurosciences.