團隊成員
研究亮點
研究成果
血管性失智團隊
團隊成員順序依英文姓名排序
失智症成因與腦血管疾病之間錯綜複雜的病生理解密團隊
全球及國內失智症病人逐年增加,而血管性失智症佔失智症病因第二位,僅次於阿茲海默症.腦中風後會引發失智症,而且腦血管疾病即使不中風還是會導致認知功能下降,過去這個領域研究較少,仍有許多未被解答的問題,治療上更是欠缺。
本中心血管性失智症團隊主要研究方向包括:腦中風後發生認知功能障礙的疾病歷程與風險因子,腦中風後神經腦血流調控的改變及其對認知功能的影響,在家遠距生物訊號在中風後認知功能變化之角色,還有腦中風後認知功能障礙的血液生物標記。未來將加入影像學分析以更全面了解腦血流與腦功能的雙向影響,進而釐清腦血流障礙在神經退化性疾病的病生理機轉。
我們團隊包括臨床醫師,流行病學專家,生物資訊專家,還有基礎神經科學研究人員,我們每月開會,建立雲端資料庫,彙整各個研究子團隊的數據,希望能找到血管性失智症的解方。
發表文章
- 1. Su, Y.-Y., Chen, C.-J., Chen, M.-H. and 6 more (...) (2026). Optimizing maternal weight gain to improve neonatal Health: A nationwide birth cohort analysis in Taiwan. Journal of the Formosan Medical Association
- 2. Kuan, Y.-C., Jhang, K.-M., Wang, W.-F. and 4 more (...) (2026). Cogstate Brief Battery performance in assessing cognitive impairment in Taiwan: A prospective, multi-center study. Journal of the Formosan Medical Association, 125(2) 191–199
- 3. Kao, S.-H., Chen, R., Su, P.-Y. and 6 more (...) (2026). A tongue resistance training program improves strength, endurance, and swallowing in frail older adults with mild cognitive impairment: a double-blind randomized controlled trial. GeroScience, 48(1) 647–660
- 4. Kuo, L.-M., Kao, W.-C.L., Chuang, Y.-H. and 1 more (...) (2026). Perspectives of New Family Caregivers of a Relative With Early-Onset Dementia: A Grounded Theory Study. Journal of Advanced Nursing, 82(1) 580–592
- 5. Chung, R.-H., Wang, C.-C., Onthoni, D.D. and 6 more (...) (2026). Elucidating the Epigenetic Landscape of Type 2 Diabetes Mellitus: A Multi-Omics Analysis Revealing Novel CpG Sites and Their Association with Cardiometabolic Traits. Diabetes and Metabolism Journal, 50(1) 153–164
- 6. Paliwal, S., Bhardwaj, J.S., Yang, C.H. and 1 more (...) (2026). Unravelling Epigenetic Modulation via MicroRNA Delivery: A Therapeutic Frontier for Alzheimer's. Molecular neurobiology, 63(1)
- 7. Lee, Y.-T., Lin, C.-Y., Lee, H.-C. and 4 more (...) (2026). Hospital-Based Combined Screening for Dementia and Depression in the Elderly: Implications for Early Mental Health Intervention. International Journal of Gerontology, 20(1) 4–10
- 8. Bamodu, O.A., Goh, Y.-X., Hong, C.-T. and 4 more (...) (2026). Explainable machine learning for neurological outcome prediction in out-of-hospital cardiac arrest survivors undergoing targeted temperature management: a multi-cohort validation study. Journal of NeuroEngineering and Rehabilitation, 23(1)
- 9. Ho, M.-H., Tsai, Y.-J., Lee, Y.-H. and 10 more (...) (2026). CCL5/RANTES signaling in inflammation dysregulation after mild traumatic brain injury. Journal of Biomedical Science, 33(1)
- 10. Chiang, C.-I., Liu, C.-C., Hao, P.-J. and 8 more (...) (2026). Plasmon-activated water reduces amyloid-β42 aggregation and exhibits neuroprotective potential in Alzheimer’s disease. Journal of the Taiwan Institute of Chemical Engineers, 181
- 11. Chen, C.-C., Hsiao, K.-Y., Lu, S.-C. and 3 more (...) (2026). Accuracy of HPV Testing Using Self-collected Urine Compared With Physician-collected Cervical Specimen for HSIL or Worse. Journal of lower genital tract disease, 30(2) 100–109
- 12. Hsieh, C.-Y., Ye, Q.-Y., Liu, F.-C. and 3 more (...) (2026). Multi-label mental health classification in social media posts with multi-perspective prompt ensemble and auxiliary self-supervision. Scientific Reports, 16(1)
- 13. Kativa, M., Balupiillai, A., Jayakumar, T. and 1 more (...) (2026). Naringin Potentiates Docetaxel-Induced Apoptosis in Breast Cancer Cells via Transient Interaction with the TUBB3 GTP-Binding Site. Cell Biochemistry and Biophysics
- 14. Sung, Y.-F., Lee, J.-T., Hu, C.-J. and 3 more (...) (2026). Impact of ALDH2 genotypes and alcohol consumption on age at first-ever ischemic stroke: A cohort study in Taiwan. Alcohol, Clinical and Experimental Research, 50(1)
- 15. Do, A.P., Shen, Y.-C., Cheng, Y.-W. and 7 more (...) (2026). Benzydamine Attenuates Matrix Metalloproteinase-9 Expression Through Inhibition of ERK MAPK in Activated Human Monocytic Cells Under Hyperglycemic Condition. Mediators of Inflammation, 2026(1)
- 16. Chen, J.-H., Chang, C.-W., Chen, Y.-Y. and 6 more (...) (2026). Chronic cerebral hypoperfusion exacerbates amyloid and tau pathology by impairing glymphatic transport via AQP4- and VEGF-mediated pathways: insights from a vascular to mixed-type dementia model. Alzheimer's and Dementia, 22(3)
- 17. Fang, H.-S., Yang, C.-M., Chang, W.-T. and 2 more (...) (2026). Quantitative analysis of the anti-VEGF effect for retinal capillary hemangiomas and vasoproliferative tumors. European Journal of Ophthalmology, 36(2) 312–320
- 18. Wu, L.-H., Kuo, Y.-H., Lin, F.-L. and 9 more (...) (2026). 3,4-dihydroxybenzalacetone from Phellinus linteus reduces glial activation, mitigates oxidative stress and inflammation, and preserves retinal function in ischemia–reperfusion-like injury. Experimental Eye Research, 262
- 19. Lin, C.-L., Chen, R., Sung, C.-M. and 6 more (...) (2026). Comparative Effectiveness of Emotion-Oriented Therapies for Behavioral and Cognitive Outcomes in People With Dementia: A Network Meta-Analysis. American Journal of Geriatric Psychiatry, 34(5) 701–715
- 20. Chen, T.-H., Su, Y.-J., Liao, W.-H. and 4 more (...) (2026). Monocyte Distribution Width as a Biomarker for Predicting Bacteremia: A Retrospective Study in the Emergency Department. Life, 16(1)
- 21. Bai, C.-H., Fan, H.-Y., Lin, H.-A. and 1 more (...) (2026). Migraines and the association of cognitive impairment: a one- and two-sample mendelian randomization analysis. Dialogues in Clinical Neuroscience, 28(1) 107–118
- 22. Kuo, L.-M., Wang, H.-P., Huang, L.-K. (2026). Client-as-Partner Care: A Grounded Theory Study of Formal Care Service Providers for Persons With Early-Onset Dementia. Journal of Advanced Nursing
- 23. Hsia, C.-H., Yang, C.-M., Chang, C.-C. and 4 more (...) (2026). Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway. Molecular Medicine Reports, 33(1)
- 24. Wang, C.-H., Jan, J.-S., Yang, C.-H. and 2 more (...) (2026). Platelets as Central Modulators of Post-Cardiac Arrest Syndrome: Mechanisms and Therapeutic Implications. Biomolecules, 16(1)
- 25. Lin, Y.-H., Chen, C.-H., Hsieh, Y.-C. and 24 more (...) (2026). Adjunct percutaneous transluminal angioplasty and stenting in endovascular thrombectomy with underlying intracranial stenosis: analysis of the TREAT-AIS registry. Journal of Neurosurgery, 144(2) 408–417
- 26. Arifin, H., Chen, R., Sung, C.-M. and 2 more (...) (2026). Performance of Malnutrition Screening Tools on People With Chronic Diseases: A Bivariate Meta-Analysis. Journal of Nursing Research, 34(1)
- 27. Sheu, J.-R., Huang, W.-C., Chang, C.-C. and 4 more (...) (2026). Distinct Thromboxane A&sub2;–Dependent Pathways Regulate Arachidonic Acid–Triggered VASP Phosphorylation at Ser239 and Ser157 in Human Platelets: Real-Time Visualization Reveals Superior Antithrombotic Efficacy by Targeting Thromboxane A&sub2; Signaling over Cyclooxygenase Inhibition. Journal of Cellular Physiology, 241(3)
- 28. Sun, J.-M., Jan, J.-S., Hsieh, C.-T. and 4 more (...) (2026). Dynamic Oxidative States: Interplay of Aging, Metabolic Stress, and Circadian Rhythms in Modulating Stroke Severity. Antioxidants, 15(1)
- 29. Banda, K.J., Chu, H., Sung, C.-M. and 6 more (...) (2026). Cortical and peripheral neurostimulation to improve swallowing function, aspiration, and dysphagia severity in dysphagia management: A network meta-analysis of randomized controlled trials. Clinical Nutrition, 57
- 30. Fajarini, M., Sung, C.-M., Lin, Y.-S. and 5 more (...) (2026). Clinical effectiveness and cost-effectiveness of primary community health care nurses: A meta-analysis. International journal of nursing studies, 177
- 31. Wang, C.-Y., Chen, C.-J., Hsieh, Y.-C. and 25 more (...) (2026). Influence of interhospital transfer on endovascular thrombectomy outcome in acute ischemic stroke patients: an analysis of the TREAT-AIS registry. Frontiers in Neurology, 17
- 32. Chan, L., Chen, J.-H., Hong, C.-T. and 5 more (...) (2026). A Phase I, Open-Label, Dose-Escalation Study to Evaluate the Safety and Tolerability of Intravenous UMC119-06 in Patients with Acute Ischemic stroke. International Journal of Medical Sciences, 23(2) 576–584
- 33. Chang, Y.-C., Arifin, H., Hung, T.-M. and 6 more (...) (2026). Innovative virtual reality exposure therapy for anxiety and posttraumatic stress disorder: a meta-analysis of randomised controlled trials. Journal of global health, 16
- 34. Kao, S.-H., Chu, H., Banda, K.J. and 6 more (...) (2026). Effects of Tongue Resistance and Strengthening Exercises on Tongue Strength and Oropharyngeal Swallowing in Frail Older Adults With Mild Cognitive Impairment: A Double-Blind Randomised Controlled Trial. Journal of Oral Rehabilitation, 53(2) 402–414
- 35. Lin, Y.-C., Hung, Y.-P., Tian, Y.-C. and 5 more (...) (2026). Clinical efficacy and safety of allogeneic adipose-derived stem cells ELIXCYTE in chronic kidney disease: a phase I/II study. Stem Cells Translational Medicine, 15(1)
- 36. Das, A., Hsu, C.-Y., Bai, C.-H. and 6 more (...) (2026). Comparative analysis of two analytical methodologies for deriving dietary patterns associated with vitamin D insufficiency and anemia among expectant mothers. International Journal of Medical Sciences, 23(1) 325–333
- 37. Yen, T.-L., Jan, J.-S., Teng, R.-D. and 5 more (...) (2026). Platelet Autophagy as a Druggable Intracellular Pathway: Therapeutic Opportunities in Thromboinflammatory Diseases. Pharmaceutics, 18(3)






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