臺北醫學大學 臺北神經醫學中心 校級神經醫學研究中心

Team to decipher the intricate pathophysiology between the causes of dementia and cerebrovascular disease

The global and domestic population of dementia patients is increasing annually, with vascular dementia ranking second only to Alzheimer’s disease in terms of etiology. Dementia can be triggered by strokes, and cerebrovascular diseases can lead to cognitive decline even without stroke. Research in this field has been relatively limited in the past, with many unanswered questions and a lack of treatment options.

Our center’s vascular dementia team focuses on various research directions, including the disease progression and risk factors for cognitive impairment after stroke, changes in neurovascular regulation after stroke and their impact on cognitive function, the role of remote biosignal monitoring in post-stroke cognitive changes at home, and blood biomarkers for cognitive impairment after stroke. In the future, we will incorporate imaging analysis to better understand the bidirectional influence of cerebral blood flow and brain function, thus elucidating the pathophysiological mechanisms of cerebral blood flow disorders in neurodegenerative diseases.

Our team consists of clinical physicians, epidemiology experts, bioinformatics specialists, and basic neuroscience researchers. We meet monthly, establish a cloud database, and aggregate data from various research sub-teams in the hope of finding a solution to vascular dementia.

Publications

• 1. Su, Y.-Y., Chen, C.-J., Chen, M.-H. and 6 more (...) (2026). Optimizing maternal weight gain to improve neonatal Health: A nationwide birth cohort analysis in Taiwan. Journal of the Formosan Medical Association
• 2. Kuan, Y.-C., Jhang, K.-M., Wang, W.-F. and 4 more (...) (2026). Cogstate Brief Battery performance in assessing cognitive impairment in Taiwan: A prospective, multi-center study. Journal of the Formosan Medical Association, 125(2) 191–199
• 3. Kao, S.-H., Chen, R., Su, P.-Y. and 6 more (...) (2026). A tongue resistance training program improves strength, endurance, and swallowing in frail older adults with mild cognitive impairment: a double-blind randomized controlled trial. GeroScience, 48(1) 647–660
• 4. Kuo, L.-M., Kao, W.-C.L., Chuang, Y.-H. and 1 more (...) (2026). Perspectives of New Family Caregivers of a Relative With Early-Onset Dementia: A Grounded Theory Study. Journal of Advanced Nursing, 82(1) 580–592
• 5. Chung, R.-H., Wang, C.-C., Onthoni, D.D. and 6 more (...) (2026). Elucidating the Epigenetic Landscape of Type 2 Diabetes Mellitus: A Multi-Omics Analysis Revealing Novel CpG Sites and Their Association with Cardiometabolic Traits. Diabetes and Metabolism Journal, 50(1) 153–164
• 6. Paliwal, S., Bhardwaj, J.S., Yang, C.H. and 1 more (...) (2026). Unravelling Epigenetic Modulation via MicroRNA Delivery: A Therapeutic Frontier for Alzheimer's. Molecular neurobiology, 63(1)
• 7. Lee, Y.-T., Lin, C.-Y., Lee, H.-C. and 4 more (...) (2026). Hospital-Based Combined Screening for Dementia and Depression in the Elderly: Implications for Early Mental Health Intervention. International Journal of Gerontology, 20(1) 4–10
• 8. Bamodu, O.A., Goh, Y.-X., Hong, C.-T. and 4 more (...) (2026). Explainable machine learning for neurological outcome prediction in out-of-hospital cardiac arrest survivors undergoing targeted temperature management: a multi-cohort validation study. Journal of NeuroEngineering and Rehabilitation, 23(1)
• 9. Ho, M.-H., Tsai, Y.-J., Lee, Y.-H. and 10 more (...) (2026). CCL5/RANTES signaling in inflammation dysregulation after mild traumatic brain injury. Journal of Biomedical Science, 33(1)
• 10. Chiang, C.-I., Liu, C.-C., Hao, P.-J. and 8 more (...) (2026). Plasmon-activated water reduces amyloid-β42 aggregation and exhibits neuroprotective potential in Alzheimer’s disease. Journal of the Taiwan Institute of Chemical Engineers, 181
• 11. Chen, C.-C., Hsiao, K.-Y., Lu, S.-C. and 3 more (...) (2026). Accuracy of HPV Testing Using Self-collected Urine Compared With Physician-collected Cervical Specimen for HSIL or Worse. Journal of lower genital tract disease, 30(2) 100–109
• 12. Hsieh, C.-Y., Ye, Q.-Y., Liu, F.-C. and 3 more (...) (2026). Multi-label mental health classification in social media posts with multi-perspective prompt ensemble and auxiliary self-supervision. Scientific Reports, 16(1)
• 13. Kativa, M., Balupiillai, A., Jayakumar, T. and 1 more (...) (2026). Naringin Potentiates Docetaxel-Induced Apoptosis in Breast Cancer Cells via Transient Interaction with the TUBB3 GTP-Binding Site. Cell Biochemistry and Biophysics
• 14. Sung, Y.-F., Lee, J.-T., Hu, C.-J. and 3 more (...) (2026). Impact of ALDH2 genotypes and alcohol consumption on age at first-ever ischemic stroke: A cohort study in Taiwan. Alcohol, Clinical and Experimental Research, 50(1)
• 15. Do, A.P., Shen, Y.-C., Cheng, Y.-W. and 7 more (...) (2026). Benzydamine Attenuates Matrix Metalloproteinase-9 Expression Through Inhibition of ERK MAPK in Activated Human Monocytic Cells Under Hyperglycemic Condition. Mediators of Inflammation, 2026(1)
• 16. Chen, J.-H., Chang, C.-W., Chen, Y.-Y. and 6 more (...) (2026). Chronic cerebral hypoperfusion exacerbates amyloid and tau pathology by impairing glymphatic transport via AQP4- and VEGF-mediated pathways: insights from a vascular to mixed-type dementia model. Alzheimer's and Dementia, 22(3)
• 17. Fang, H.-S., Yang, C.-M., Chang, W.-T. and 2 more (...) (2026). Quantitative analysis of the anti-VEGF effect for retinal capillary hemangiomas and vasoproliferative tumors. European Journal of Ophthalmology, 36(2) 312–320
• 18. Wu, L.-H., Kuo, Y.-H., Lin, F.-L. and 9 more (...) (2026). 3,4-dihydroxybenzalacetone from Phellinus linteus reduces glial activation, mitigates oxidative stress and inflammation, and preserves retinal function in ischemia–reperfusion-like injury. Experimental Eye Research, 262
• 19. Lin, C.-L., Chen, R., Sung, C.-M. and 6 more (...) (2026). Comparative Effectiveness of Emotion-Oriented Therapies for Behavioral and Cognitive Outcomes in People With Dementia: A Network Meta-Analysis. American Journal of Geriatric Psychiatry, 34(5) 701–715
• 20. Chen, T.-H., Su, Y.-J., Liao, W.-H. and 4 more (...) (2026). Monocyte Distribution Width as a Biomarker for Predicting Bacteremia: A Retrospective Study in the Emergency Department. Life, 16(1)
• 21. Bai, C.-H., Fan, H.-Y., Lin, H.-A. and 1 more (...) (2026). Migraines and the association of cognitive impairment: a one- and two-sample mendelian randomization analysis. Dialogues in Clinical Neuroscience, 28(1) 107–118
• 22. Kuo, L.-M., Wang, H.-P., Huang, L.-K. (2026). Client-as-Partner Care: A Grounded Theory Study of Formal Care Service Providers for Persons With Early-Onset Dementia. Journal of Advanced Nursing
• 23. Hsia, C.-H., Yang, C.-M., Chang, C.-C. and 4 more (...) (2026). Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway. Molecular Medicine Reports, 33(1)
• 24. Wang, C.-H., Jan, J.-S., Yang, C.-H. and 2 more (...) (2026). Platelets as Central Modulators of Post-Cardiac Arrest Syndrome: Mechanisms and Therapeutic Implications. Biomolecules, 16(1)
• 25. Lin, Y.-H., Chen, C.-H., Hsieh, Y.-C. and 24 more (...) (2026). Adjunct percutaneous transluminal angioplasty and stenting in endovascular thrombectomy with underlying intracranial stenosis: analysis of the TREAT-AIS registry. Journal of Neurosurgery, 144(2) 408–417
• 26. Arifin, H., Chen, R., Sung, C.-M. and 2 more (...) (2026). Performance of Malnutrition Screening Tools on People With Chronic Diseases: A Bivariate Meta-Analysis. Journal of Nursing Research, 34(1)
• 27. Sheu, J.-R., Huang, W.-C., Chang, C.-C. and 4 more (...) (2026). Distinct Thromboxane A&sub2;–Dependent Pathways Regulate Arachidonic Acid–Triggered VASP Phosphorylation at Ser239 and Ser157 in Human Platelets: Real-Time Visualization Reveals Superior Antithrombotic Efficacy by Targeting Thromboxane A&sub2; Signaling over Cyclooxygenase Inhibition. Journal of Cellular Physiology, 241(3)
• 28. Sun, J.-M., Jan, J.-S., Hsieh, C.-T. and 4 more (...) (2026). Dynamic Oxidative States: Interplay of Aging, Metabolic Stress, and Circadian Rhythms in Modulating Stroke Severity. Antioxidants, 15(1)
• 29. Banda, K.J., Chu, H., Sung, C.-M. and 6 more (...) (2026). Cortical and peripheral neurostimulation to improve swallowing function, aspiration, and dysphagia severity in dysphagia management: A network meta-analysis of randomized controlled trials. Clinical Nutrition, 57
• 30. Fajarini, M., Sung, C.-M., Lin, Y.-S. and 5 more (...) (2026). Clinical effectiveness and cost-effectiveness of primary community health care nurses: A meta-analysis. International journal of nursing studies, 177
• 31. Wang, C.-Y., Chen, C.-J., Hsieh, Y.-C. and 25 more (...) (2026). Influence of interhospital transfer on endovascular thrombectomy outcome in acute ischemic stroke patients: an analysis of the TREAT-AIS registry. Frontiers in Neurology, 17
• 32. Chan, L., Chen, J.-H., Hong, C.-T. and 5 more (...) (2026). A Phase I, Open-Label, Dose-Escalation Study to Evaluate the Safety and Tolerability of Intravenous UMC119-06 in Patients with Acute Ischemic stroke. International Journal of Medical Sciences, 23(2) 576–584
• 33. Chang, Y.-C., Arifin, H., Hung, T.-M. and 6 more (...) (2026). Innovative virtual reality exposure therapy for anxiety and posttraumatic stress disorder: a meta-analysis of randomised controlled trials. Journal of global health, 16
• 34. Kao, S.-H., Chu, H., Banda, K.J. and 6 more (...) (2026). Effects of Tongue Resistance and Strengthening Exercises on Tongue Strength and Oropharyngeal Swallowing in Frail Older Adults With Mild Cognitive Impairment: A Double-Blind Randomised Controlled Trial. Journal of Oral Rehabilitation, 53(2) 402–414
• 35. Lin, Y.-C., Hung, Y.-P., Tian, Y.-C. and 5 more (...) (2026). Clinical efficacy and safety of allogeneic adipose-derived stem cells ELIXCYTE in chronic kidney disease: a phase I/II study. Stem Cells Translational Medicine, 15(1)
• 36. Das, A., Hsu, C.-Y., Bai, C.-H. and 6 more (...) (2026). Comparative analysis of two analytical methodologies for deriving dietary patterns associated with vitamin D insufficiency and anemia among expectant mothers. International Journal of Medical Sciences, 23(1) 325–333
• 37. Yen, T.-L., Jan, J.-S., Teng, R.-D. and 5 more (...) (2026). Platelet Autophagy as a Druggable Intracellular Pathway: Therapeutic Opportunities in Thromboinflammatory Diseases. Pharmaceutics, 18(3)