臺北醫學大學 臺北神經醫學中心 校級神經醫學研究中心

北醫神經婦幼團隊

北醫神經婦幼團隊由公衛學院陳怡樺院長帶領，結合了公衛精神流行病學與環境科學專家、婦產小兒神經與早療臨床醫師組成專業團隊，因應當前少子化危機，關注嬰幼兒發展能否順應環境的巨大變動，並經由長期追蹤探討環境對於孩童身心健康的影響。本團隊自2009年積極投入此議題，並共同為嬰幼兒成長與健康努力，同時關注父母親的整體身心狀態，認為家庭整體健康為社區、群體乃至於國家未來發展之重要關鍵。

本團隊在當前以科技導入健康之重要契機，持續擴充大型「臺灣孕產期健康追蹤研究」長期追蹤資料庫優勢，最大特色莫過於納入影響幼兒發展舉足輕重卻少有文獻支持之議題，包括睡眠、多媒體使用、飲食習慣、室內室外空氣污染與重金屬暴露等之危害。過去研究對象大多集中於3-12歲的兒童，並已指出危害與風險，然針對1-3歲幼兒關鍵期的研究明顯不足，且鮮少能對嬰幼兒以長期追蹤研究整合探討各因子連動與交互作用，及其對幼兒認知語言發展之權重影響力，因此本團隊之特色為利用長期追蹤資料結合家訪採樣調查、收集親子之睡眠品質與體內重金屬含量、家戶環境與空氣品質採樣以及幼兒語言發展與腦部神經發展狀況，再經由人工智慧多模態資訊平台，建立幼兒神經發展預測模型，並有助於醫事人員選取適當的早療決策，進而達到預防醫學與精準公衛之願景。

發表文章

• 1. Su, Y.-Y., Chen, C.-J., Chen, M.-H. and 6 more (...) (2025). Long-term effects on growth in preterm and small for gestational age infants: A national birth cohort study. Pediatrics and Neonatology, 66(2) 168–175
• 2. Yang, H.-C., Kwok, P.-Y., Li, L.-H. and 140 more (...) (2025). The Taiwan Precision Medicine Initiative provides a cohort for large-scale studies. Nature, 648(8092) 117–127
• 3. Palanivelu, L., Chang, C.-W., Li, S.-J. and 3 more (...) (2025). Interplay of Neuroinflammation and Gut Microbiota Dysbiosis in Alzheimer’s Disease Using Diffusion Kurtosis Imaging Biomarker in 3 × Tg-AD Mouse Models. ACS Chemical Neuroscience, 16(8) 1511–1528
• 4. Lee, G.A., Chang, Y.-W., Lai, J.-H. and 11 more (...) (2025). CCN1 Is a Therapeutic Target for Reperfused Ischemic Brain Injury. Translational Stroke Research, 16(4) 1044–1061
• 5. Usman, M., Lin, W.-Y., Lin, Y.-Y. and 4 more (...) (2025). Classifying developmental delays with EEG: A comparative study of machine learning and deep learning approaches. Biocybernetics and Biomedical Engineering, 45(2) 229–246
• 6. Tsai, M.-L., Hsieh, K.L.-C., Liu, Y.-L. and 4 more (...) (2025). Morphometric and radiomics analysis toward the prediction of epilepsy associated with supratentorial low-grade glioma in children. Cancer Imaging, 25(1)
• 7. Liu, Y.-H., Lee, Y.-L., Han, C.-L. and 12 more (...) (2025). ITIH4 alleviates OVA-induced asthma by regulating lung-gut microbiota. Molecular Medicine, 31(1)
• 8. Kuo, Y.-T., Wang, H.-L., Chen, B.-W. and 5 more (...) (2025). Degradation-aware neural imputation: Advancing decoding stability in brain machine interfaces. APL Bioengineering, 9(2)
• 9. Su, Y.-Y., Chen, C.-J., Chen, M.-H. and 6 more (...) (2026). Optimizing maternal weight gain to improve neonatal Health: A nationwide birth cohort analysis in Taiwan. Journal of the Formosan Medical Association
• 10. Su, Y.-Y., Chen, C.-J., Chen, M.-H. and 7 more (...) (2025). Revisiting maternal age and child health: A nationwide birth cohort study in Taiwan. Journal of the Formosan Medical Association
• 11. Phiri, Y.V.A., Chen, Y.-H., Zou, M.-L. and 8 more (...) (2025). Impact of urban residential environment and biological agents on childhood allergic diseases: Insights from the Greater Taipei area. International Journal of Hygiene and Environmental Health, 269
• 12. Kuo, C.-Y., Chang, H., Chia-Yu Su, E. and 3 more (...) (2026). Effectiveness of early intervention and prediction of outcomes in taiwanese children with developmental delay. Pediatrics and Neonatology, 67(1) 63–69
• 13. Zou, M.-L., Candice Lung, S.-C., Wu, C.-D. and 8 more (...) (2025). Heat exposure and adverse birth outcomes: Modification by residential greenness in a 14-year prospective cohort study in Taiwan. Environmental Research, 285
• 14. Riskawati, Y.K., Lin, C.-Y., Niwa, A. and 1 more (...) (2025). Enhancing Skeletal Muscle Fiber Type Transition Through Substrate Coating Alteration in Myoblast Cell Culture. International Journal of Molecular Sciences, 26(12)
• 15. Palanivelu, L., Chen, Y.-Y., Liang, Y.-W. and 4 more (...) (2025). Diffusion kurtosis imaging biomarkers associated with amelioration of neuroinflammation, gray matter microstructural abnormalities, and gut dysbiosis by central thalamic deep brain stimulation in autistic -like young rats. NeuroImage, 317
• 16. Tsai, P.-L., Lo, Y.-C., Tsai, Y.-S. and 7 more (...) (2026). Tract integrity predicts neurological outcomes in neonatal hypoxic-ischemic encephalopathy. Pediatrics and Neonatology, 67(1) 56–62
• 17. Li Lin, C.-Y., Huang, Y.-J., Lin, H.-C. and 4 more (...) (2026). Increased incidence of attention-deficit/hyperactivity disorder is associated with early and prolonged exposure to antibiotics: A population-based retrospective cohort study. Pediatrics and Neonatology, 67(1) 45–50
• 18. Yoashi, N.T., Hsu, C.-J., Wang, Y.-L. and 4 more (...) (2025). Novel synthesis and application of biochar for controlling release and exposure of mercury in the farmland: From human health risk perspective. Environmental Research, 276
• 19. Lin, D.-X., Chang, Y.-T., Lo, Y.-C. and 1 more (...) (2025). Impact of ASD and ADHD on pediatric asthma exacerbations: a retrospective analysis of the Nationwide Inpatient Sample 2005–2020. Italian Journal of Pediatrics, 51(1)
• 20. Chin, W.-S., Chuang, Y.-N., Hung, W.-L. and 7 more (...) (2025). Association Between Urinary Paraben Concentrations and Early Renal Impairment in Young Adults in Taiwan. Exposure and Health, 17(2) 455–465
• 21. Fergus, D.N., Chen, Y.-H., Chuang, Y.-C. and 2 more (...) (2025). A Stratified Cross Section of Resilience in Older Taiwanese Men and Women. Asia-Pacific Journal of Public Health, 37(1) 85–92
• 22. Tsai, J.-J., Su, Y.-Y., Chang, H. and 3 more (...) (2025). Practices for introducing complementary foods in Taiwan: A nationwide survey from 2013 to 2016. Journal of the Formosan Medical Association, 124(11) 1045–1049
• 23. Kao, C.-S., Jiang, C.-B., Yang, C.-C. and 5 more (...) (2026). Combined exposure to microplastics and cadmium alters gut microbiota composition in preschool children: A cross-sectional study. Journal of Hazardous Materials, 501
• 24. Huang, Z.-Y., Syu, C.-H., Chien, L.-C. and 1 more (...) (2025). Corrigendum to: “Probabilistic health risk assessment of rare earth elements through rice (Oryza sativa L.) consumption using Monte Carlo simulation” (Food Chemistry, (2025), 496, P2, (146760), (S0308814625040129), 10.1016/j.foodchem.2025.146760). Food Chemistry, 495
• 25. Kao, C.-S., Wang, Y.-L., Jiang, C.-B. and 6 more (...) (2026). A risk-benefit assessment of dietary selenium and its implications in preschool children’s growth performance in Taiwan. Environmental Health and Preventive Medicine, 31
• 26. Huang, Y.-J., Li, Y.-T., Tsai, M.-L. and 5 more (...) (2025). Photobiomodulation as a therapeutic approach for attention-deficit/hyperactivity disorder in model rats. Lasers in Medical Science, 40(1)
• 27. Su, Y.-Y., Chen, C.-J., Chen, M.-H. and 7 more (...) (2026). Atopic diseases in pediatric population: prematurity and small for gestational age. BMC Pediatrics, 26(1)
• 28. Chakranon, P., Huang, J.-P., Au, H.-K. and 7 more (...) (2026). Bidirectional associations between smart device use and body mass index among children aged 3 to 5 years: a longitudinal study. International Journal of Behavioral Nutrition and Physical Activity, 23(1)
• 29. Chu, C.-Y., Chen, Z.-H., Liang, C.-W. and 12 more (...) (2026). A Closed-Loop-Capable Neural Interface Platform for Deep Brain Modulation via Integrated Non-Viral Gene Delivery, NIR Optogenetics, and Electrophysiological Recording. Advanced Science, 13(7)
• 30. Chiu, F.-M., Chai, J.-W., Fang, Y.-T. and 5 more (...) (2025). Reduction of respiratory motion artifacts in free-breathing abdominal MRI using strategic averaging of reassembled k-space data with Self-Modeled respiratory state sorting. Physica Medica, 139
• 31. Chao, W.-C., Zou, M.-L., Wu, C.-D. and 9 more (...) (2026). Prenatal and postpartum residential greenness and behavioral development in early Childhood: Findings from a birth cohort. Environmental Research, 295
• 32. Wong, P.-Y., Su, H.-J., Chao, H.J. and 7 more (...) (2026). An Innovative Geo-AI Approach in Estimating High-Resolution Urban Ambient Fungal Spore Variations. Earth Systems and Environment, 10(1) 31–44
• 33. Lin, W.-L., Chang, C.-C., Chen, S.-H. and 9 more (...) (2025). Exercise-induced weight loss modulates brain iron and Omega-3 fatty acid metabolism in middle-aged obese rats. Nutrition, 139
• 34. Liu, Y.-H., Lee, Y.-L., Han, C.-L. and 12 more (...) (2025). Correction to: ITIH4 alleviates OVA-induced asthma by regulating lung-gut microbiota (Molecular Medicine, (2025), 31, 1, (204), 10.1186/s10020-025-01270-x). Molecular Medicine, 31(1)
• 35. Sun, Y.-H., Tseng, S.-H., Hou, W.-H. and 3 more (...) (2026). Impact of extended reality interventions on core deficits and functional performance among individuals with autism spectrum disorder: A systematic review and meta-analysis. European Child and Adolescent Psychiatry, 35(2) 321–339
• 36. Lee, G.A., Chang, Y.-W., Yang, Y.-C.S.H. and 8 more (...) (2025). Two-hit perinatal injuries cause gut microbial dysbiosis in offspring. Neuroscience, 589 185–193