臺北醫學大學 臺北神經醫學中心 校級神經醫學研究中心

Child Development Team

Our collaborative team, with the Principle Investigator of Dr. Yi-Hua Chen, Dean of the College of Public Health, brings together diverse expertise in epidemiology, environmental science, and clinical practice specializing in maternal and child neurology and early intervention. Our mission is to investigate the adaptability of infants and young children to considerable environmental shifts and examine the lasting effects of these changes on their physical and mental well-being amidst declining birth rates in Taiwan. Since 2009, we have actively pursued this endeavor, striving to promote the comprehensive health and development of infants and young children while also considering the holistic well-being of their parents.

Harnessing the opportunities presented by advancements in technology-driven healthcare, we continuously expand our extensive database through the Longitudinal Examination across Prenatal and Postpartum Health in Taiwan (LEAPP-HIT) project. Our distinctive approach lies in exploring crucial yet underexplored factors influencing child development, such as sleep patterns, digital media usage, dietary habits, environmental pollution, and exposure to toxic metals. While prior studies have primarily focused on older children aged 3-12, identifying risks and hazards, there remains a notable gap in research during the critical 1-3 year period. Our team addresses this gap by conducting longitudinal studies that integrate various factors and assess their weighted impact on cognitive and language development.

Publications

• 1. Su, Y.-Y., Chen, C.-J., Chen, M.-H. and 6 more (...) (2025). Long-term effects on growth in preterm and small for gestational age infants: A national birth cohort study. Pediatrics and Neonatology, 66(2) 168–175
• 2. Yang, H.-C., Kwok, P.-Y., Li, L.-H. and 140 more (...) (2025). The Taiwan Precision Medicine Initiative provides a cohort for large-scale studies. Nature, 648(8092) 117–127
• 3. Palanivelu, L., Chang, C.-W., Li, S.-J. and 3 more (...) (2025). Interplay of Neuroinflammation and Gut Microbiota Dysbiosis in Alzheimer’s Disease Using Diffusion Kurtosis Imaging Biomarker in 3 × Tg-AD Mouse Models. ACS Chemical Neuroscience, 16(8) 1511–1528
• 4. Lee, G.A., Chang, Y.-W., Lai, J.-H. and 11 more (...) (2025). CCN1 Is a Therapeutic Target for Reperfused Ischemic Brain Injury. Translational Stroke Research, 16(4) 1044–1061
• 5. Usman, M., Lin, W.-Y., Lin, Y.-Y. and 4 more (...) (2025). Classifying developmental delays with EEG: A comparative study of machine learning and deep learning approaches. Biocybernetics and Biomedical Engineering, 45(2) 229–246
• 6. Tsai, M.-L., Hsieh, K.L.-C., Liu, Y.-L. and 4 more (...) (2025). Morphometric and radiomics analysis toward the prediction of epilepsy associated with supratentorial low-grade glioma in children. Cancer Imaging, 25(1)
• 7. Liu, Y.-H., Lee, Y.-L., Han, C.-L. and 12 more (...) (2025). ITIH4 alleviates OVA-induced asthma by regulating lung-gut microbiota. Molecular Medicine, 31(1)
• 8. Kuo, Y.-T., Wang, H.-L., Chen, B.-W. and 5 more (...) (2025). Degradation-aware neural imputation: Advancing decoding stability in brain machine interfaces. APL Bioengineering, 9(2)
• 9. Su, Y.-Y., Chen, C.-J., Chen, M.-H. and 6 more (...) (2026). Optimizing maternal weight gain to improve neonatal Health: A nationwide birth cohort analysis in Taiwan. Journal of the Formosan Medical Association
• 10. Su, Y.-Y., Chen, C.-J., Chen, M.-H. and 7 more (...) (2025). Revisiting maternal age and child health: A nationwide birth cohort study in Taiwan. Journal of the Formosan Medical Association
• 11. Phiri, Y.V.A., Chen, Y.-H., Zou, M.-L. and 8 more (...) (2025). Impact of urban residential environment and biological agents on childhood allergic diseases: Insights from the Greater Taipei area. International Journal of Hygiene and Environmental Health, 269
• 12. Kuo, C.-Y., Chang, H., Chia-Yu Su, E. and 3 more (...) (2026). Effectiveness of early intervention and prediction of outcomes in taiwanese children with developmental delay. Pediatrics and Neonatology, 67(1) 63–69
• 13. Zou, M.-L., Candice Lung, S.-C., Wu, C.-D. and 8 more (...) (2025). Heat exposure and adverse birth outcomes: Modification by residential greenness in a 14-year prospective cohort study in Taiwan. Environmental Research, 285
• 14. Riskawati, Y.K., Lin, C.-Y., Niwa, A. and 1 more (...) (2025). Enhancing Skeletal Muscle Fiber Type Transition Through Substrate Coating Alteration in Myoblast Cell Culture. International Journal of Molecular Sciences, 26(12)
• 15. Palanivelu, L., Chen, Y.-Y., Liang, Y.-W. and 4 more (...) (2025). Diffusion kurtosis imaging biomarkers associated with amelioration of neuroinflammation, gray matter microstructural abnormalities, and gut dysbiosis by central thalamic deep brain stimulation in autistic -like young rats. NeuroImage, 317
• 16. Tsai, P.-L., Lo, Y.-C., Tsai, Y.-S. and 7 more (...) (2026). Tract integrity predicts neurological outcomes in neonatal hypoxic-ischemic encephalopathy. Pediatrics and Neonatology, 67(1) 56–62
• 17. Li Lin, C.-Y., Huang, Y.-J., Lin, H.-C. and 4 more (...) (2026). Increased incidence of attention-deficit/hyperactivity disorder is associated with early and prolonged exposure to antibiotics: A population-based retrospective cohort study. Pediatrics and Neonatology, 67(1) 45–50
• 18. Yoashi, N.T., Hsu, C.-J., Wang, Y.-L. and 4 more (...) (2025). Novel synthesis and application of biochar for controlling release and exposure of mercury in the farmland: From human health risk perspective. Environmental Research, 276
• 19. Lin, D.-X., Chang, Y.-T., Lo, Y.-C. and 1 more (...) (2025). Impact of ASD and ADHD on pediatric asthma exacerbations: a retrospective analysis of the Nationwide Inpatient Sample 2005–2020. Italian Journal of Pediatrics, 51(1)
• 20. Chin, W.-S., Chuang, Y.-N., Hung, W.-L. and 7 more (...) (2025). Association Between Urinary Paraben Concentrations and Early Renal Impairment in Young Adults in Taiwan. Exposure and Health, 17(2) 455–465
• 21. Fergus, D.N., Chen, Y.-H., Chuang, Y.-C. and 2 more (...) (2025). A Stratified Cross Section of Resilience in Older Taiwanese Men and Women. Asia-Pacific Journal of Public Health, 37(1) 85–92
• 22. Tsai, J.-J., Su, Y.-Y., Chang, H. and 3 more (...) (2025). Practices for introducing complementary foods in Taiwan: A nationwide survey from 2013 to 2016. Journal of the Formosan Medical Association, 124(11) 1045–1049
• 23. Kao, C.-S., Jiang, C.-B., Yang, C.-C. and 5 more (...) (2026). Combined exposure to microplastics and cadmium alters gut microbiota composition in preschool children: A cross-sectional study. Journal of Hazardous Materials, 501
• 24. Huang, Z.-Y., Syu, C.-H., Chien, L.-C. and 1 more (...) (2025). Corrigendum to: “Probabilistic health risk assessment of rare earth elements through rice (Oryza sativa L.) consumption using Monte Carlo simulation” (Food Chemistry, (2025), 496, P2, (146760), (S0308814625040129), 10.1016/j.foodchem.2025.146760). Food Chemistry, 495
• 25. Kao, C.-S., Wang, Y.-L., Jiang, C.-B. and 6 more (...) (2026). A risk-benefit assessment of dietary selenium and its implications in preschool children’s growth performance in Taiwan. Environmental Health and Preventive Medicine, 31
• 26. Huang, Y.-J., Li, Y.-T., Tsai, M.-L. and 5 more (...) (2025). Photobiomodulation as a therapeutic approach for attention-deficit/hyperactivity disorder in model rats. Lasers in Medical Science, 40(1)
• 27. Su, Y.-Y., Chen, C.-J., Chen, M.-H. and 7 more (...) (2026). Atopic diseases in pediatric population: prematurity and small for gestational age. BMC Pediatrics, 26(1)
• 28. Chakranon, P., Huang, J.-P., Au, H.-K. and 7 more (...) (2026). Bidirectional associations between smart device use and body mass index among children aged 3 to 5 years: a longitudinal study. International Journal of Behavioral Nutrition and Physical Activity, 23(1)
• 29. Chu, C.-Y., Chen, Z.-H., Liang, C.-W. and 12 more (...) (2026). A Closed-Loop-Capable Neural Interface Platform for Deep Brain Modulation via Integrated Non-Viral Gene Delivery, NIR Optogenetics, and Electrophysiological Recording. Advanced Science, 13(7)
• 30. Chiu, F.-M., Chai, J.-W., Fang, Y.-T. and 5 more (...) (2025). Reduction of respiratory motion artifacts in free-breathing abdominal MRI using strategic averaging of reassembled k-space data with Self-Modeled respiratory state sorting. Physica Medica, 139
• 31. Chao, W.-C., Zou, M.-L., Wu, C.-D. and 9 more (...) (2026). Prenatal and postpartum residential greenness and behavioral development in early Childhood: Findings from a birth cohort. Environmental Research, 295
• 32. Wong, P.-Y., Su, H.-J., Chao, H.J. and 7 more (...) (2026). An Innovative Geo-AI Approach in Estimating High-Resolution Urban Ambient Fungal Spore Variations. Earth Systems and Environment, 10(1) 31–44
• 33. Lin, W.-L., Chang, C.-C., Chen, S.-H. and 9 more (...) (2025). Exercise-induced weight loss modulates brain iron and Omega-3 fatty acid metabolism in middle-aged obese rats. Nutrition, 139
• 34. Liu, Y.-H., Lee, Y.-L., Han, C.-L. and 12 more (...) (2025). Correction to: ITIH4 alleviates OVA-induced asthma by regulating lung-gut microbiota (Molecular Medicine, (2025), 31, 1, (204), 10.1186/s10020-025-01270-x). Molecular Medicine, 31(1)
• 35. Sun, Y.-H., Tseng, S.-H., Hou, W.-H. and 3 more (...) (2026). Impact of extended reality interventions on core deficits and functional performance among individuals with autism spectrum disorder: A systematic review and meta-analysis. European Child and Adolescent Psychiatry, 35(2) 321–339
• 36. Lee, G.A., Chang, Y.-W., Yang, Y.-C.S.H. and 8 more (...) (2025). Two-hit perinatal injuries cause gut microbial dysbiosis in offspring. Neuroscience, 589 185–193