Platelet neurotrophins for neurorestorative biotherapy


David Blum Research Director at Inserm
- Nationality: France
Specialty:
- Molecular and cellular processes involved in neurodegenerative diseases, particularly Huntington's and Alzheimer's Disease using in vivo approaches (transgenic models, conditional approaches, viral approaches)

David Devos Professor of University Lille
- Nationality: France
Specialty:
- Translational and clinical development of new therapeutic strategies for neurodegenerative diseases (Parkinson's disease & amyotrophic lateral sclerosis) notably based upon platelet lysate for regenerative medicine

Liling Delila Ph.D. student
- Nationality: Indonesia
Specialty:
- Neuroprotective activity of platelet extracellular vesicles in Parkinson's Disease

Kirti Gupta Ph.D. student
- Nationality: Indonesia

NNhi Thao Ngoc Le Ph.D. student
- Nationality: Vietnam

Nguyen Tran Hai Yen Ph.D. student
- Nationality: Vietnam
Specialty:
- Using platelet-derived extracellular vesicles (pEVs) loaded with drugs to test on Glioblastoma cells, aiming towards brain cancer treatment

Li-De Su Ph.D. student

Ncobile Bagezile Mdlovu Ph.D. student
- Nationality: Switzerland

Ariunjargal Nymredene Ph.D. student
- Nationality: Mongolia
Specialty:
- The functional role of extracellular vesicles (EVs) derived from human platelets in neurogenesis
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Abinaya Srinivasan Ph.D. student
- Nationality: India
Specialty:
- The therapeutic potential of platelet secretome in promoting neurogenesis and olfactory regeneration through neuroprotective approaches
Alphabet order of last name.
Research Spotlight
Platelet lysates and extracellular vesicles
Nanotechnology for regenerative medicine and cell therapy
Treatment of neurodegenerative diseases and traumatic brain injury
Research Results
- 1. Livkisa, D., Chang, T.-H., Burnouf, T. and 6 more (...) (2024). Extracellular vesicles purified from serum-converted human platelet lysates offer strong protection after cardiac ischaemia/reperfusion injury. Biomaterials, 306
- 2. Lin, J.-C., Kaswan, K., Chatterjee, S. and 13 more (...) (2024). CuO NWs boosted triboelectric microfluidic nanosensor functionalized by collagen-protein interactions for real-time platelet count monitoring. Chemical Engineering Journal, 490
- 3. Wu, S.-H., Rethi, L., Pan, W.-Y. and 2 more (...) (2024). Emerging horizons and prospects of polysaccharide-constructed gels in the realm of wound healing. Colloids and Surfaces B: Biointerfaces, 235
- 4. Burnouf, T., Epstein, J., Faber, J.-C. and 1 more (...) (2024). Stepwise options for preparing therapeutic plasma proteins from domestic plasma in low- and middle-income countries. Vox Sanguinis, 119(2) 102–109
- 5. Delila, L., Nebie, O., Le, N.T.N. and 9 more (...) (2024). Neuroprotective effects of intranasal extracellular vesicles from human platelet concentrates supernatants in traumatic brain injury and Parkinson’s disease models. Journal of Biomedical Science, 31(1)
- 6. Le, N.T.N., Han, C.-L., Delila, L. and 6 more (...) (2024). Proteomics of human platelet lysates and insight from animal studies on platelet protein diffusion to hippocampus upon intranasal administration. APL Bioengineering, 8(2)
- 7. Lin, C.-W., Liu, T.-H., Chen, V. and 3 more (...) (2024). Synergistic potential of gellan gum methacrylate and keratin hydrogel for visceral hemostasis and skin tissue regeneration. Materials Today Bio, 27
- 8. Chuang, E.-Y., Lin, Y.-C., Huang, Y.-M. and 8 more (...) (2024). Biofunctionalized hydrogel composed of genipin-crosslinked gelatin/hyaluronic acid incorporated with lyophilized platelet-rich fibrin for segmental bone defect repair. Carbohydrate Polymers, 339
- 9. Chen, S.-H., Wang, H.-W., Yang, P.-C. and 11 more (...) (2024). Schwann cells acquire a repair phenotype after assembling into spheroids and show enhanced in vivo therapeutic potential for promoting peripheral nerve repair. Bioengineering and Translational Medicine, 9(2)
- 10. Liu, K.-T., Wang, P.-W., Hsieh, H.-Y. and 14 more (...) (2024). Site-specific thrombus formation: advancements in photothrombosis-on-a-chip technology. Lab on a Chip, 24(14) 3422–3433
- 11. Don, T.-M., Hong, Y.-T., Jheng, P.-R. and 2 more (...) (2024). Improved camptothecin encapsulation and efficacy by environmentally sensitive block copolymer/chitosan/fucoidan nanoparticles for targeting lung cancer cells. International Journal of Biological Macromolecules, 277
- 12. Rethi, L., Wong, C.-C., Liu, W.-J. and 4 more (...) (2024). Self-adaptable calcium-based bioactive phosphosilicate-infused gelatin-hyaluronic hydrogel for orthopedic regeneration. International Journal of Biological Macromolecules, 256
- 13. Chen, Y.-C., Chuang, E.-Y., Tu, Y.-K. and 2 more (...) (2024). Human platelet lysate-cultured adipose-derived stem cell sheets promote angiogenesis and accelerate wound healing via CCL5 modulation. Stem Cell Research and Therapy, 15(1)
- 14. Yeh, W.-T., Yu, E.Y.-L., Lu, Y.-H. and 3 more (...) (2024). Bioprocessing of human platelet concentrates to generate lysates and extracellular vesicles for therapeutic applications. MethodsX, 13
- 15. Ho, M.-H., Tsai, Y.-J., Chen, C.-Y. and 6 more (...) (2024). CCL5 is essential for axonogenesis and neuronal restoration after brain injury. Journal of Biomedical Science, 31(1)
- 16. Burnouf, T., Epstein, J., Faber, J.-C. and 1 more (...) (2024). Response to comments from the International Patient Organization for Primary Immunodeficiencies on ‘Stepwise options for preparing therapeutic plasma proteins from domestic plasma in low- and middle-income countries’. Vox Sanguinis, 119(9) 1023–1024
- 17. Quiñones, E.D., Wang, M.-H., Liu, K.-T. and 10 more (...) (2024). Extracellular vesicles from human adipose-derived stem cell spheroids: Characterization and therapeutic implications in diabetic wound healing. Materials Today Bio, 29