臺北醫學大學 臺北神經醫學中心 校級神經醫學研究中心

Research Spotlight

Sng should be considered as a unique symptom differing from pain because current treatment for soreness is unsatisfied and a different underlying mechanism underpinning sng development has been suggested. However, sng is largely ignored because sng may be treated as a mild form of pain when it commonly coexists with pain. In Chinese society, pain is often described as a compound word “sng(acid)-pain” (痠痛), in which sng (pronounced as sə-ng) is a Taiwanese word that represents the state of feeling sore (or tissue acidosis). In pain clinic, soreness (or “sng”) is not only a characteristic sensory phenotype of various acute and chronic pain syndromes (e.g., delayed onset muscle soreness, fibromyalgia, and radicular pain), but also a sign of successful analgesia for acupuncture and many forms of physical therapy. Thus, the nature of soreness (sng) is not always nociceptive and should be defined as a way to distinguish it from pain. However, in English dictionary, soreness means the quality of being painful and uncomfortable because of injury or too much use. To facilitate the investigation of molecular and neurobiological mechanism of soreness sensation and its clinical impact, we have proposed a novel theory of “sngception (sng- ception)” to describe the response of the somatosensory nervous system to sense tissue acidosis and distinguish it from nociception

Our long-range goal is to establish a new concept in treating chronic sng-pain associated with tissue acidosis. The objective is to probe the molecular determinants and sensory neuron subtypes involved in sngception and distinguish it from nociception. Our central hypothesis is that sngception is distinguishable from nociception; and proprioceptors are one of the neuron subtypes involved in sngception. The hypothesis is based on our preliminary data that showed conditional knockout ASIC3 in proprioceptors but not nociceptors abolished the acid-induced chronic sng-pain and proprioceptors play an important role in pain chronicity. Also, we have found the segregation of sngception from nociception in a spine-injury patient who lost most somatosensory function in his right leg, but maintained proprioception and motor function; whereas the patient felt sng of right leg after a long-distance walking. In addition, Sng has differential impacts from pain on functional brain networks and health-related quality of life in Taiwanese chronic low back pain patients.

Research Results

Publications：

• 1. Kao, C.-S., Wang, Y.-L., Jiang, C.-B. and 7 more (...) (2024). Assessment of sources and health risks of heavy metals in metropolitan household dust among preschool children: The LEAPP-HIT study. Journal of Environmental Management, 352
• 2. Rohmah, I., Chen, Y.-C., Lin, C.-J. and 2 more (...) (2024). Diagnostic accuracy of the pediatric CAM-ICU, pre-school CAM-ICU, Pediatric Anesthesia Emergence Delirium and Cornell Assessment of Pediatric Delirium for detecting delirium in the pediatric intensive care unit: A systematic review and meta-analysis. Intensive and Critical Care Nursing, 82
• 3. Laiman, V., Chuang, H.-C., Lo, Y.-C. and 6 more (...) (2024). Cigarette smoke-induced dysbiosis: comparative analysis of lung and intestinal microbiomes in COPD mice and patients. Respiratory Research, 25(1)
• 4. Vo, N.T., Tu, Y.-K., Lin, K.-C. and 2 more (...) (2024). Diagnostic Accuracy of the FRAIL Scale, Groningen Frailty Indicator, Tilburg Frailty Indicator, and PRISMA-7 for Frailty Screening Among Older Adults in Community Settings: A Systematic Review and Network Meta-Analysis. Gerontologist, 64(6)
• 5. Chen, Y.-C., Foster, J., Wang, M.-L. and 3 more (...) (2024). Global prevalence and risk factors of emergence delirium in pediatric patients undergoing general anesthesia: A systemic review and meta-analysis. Journal of Pediatric Nursing, 77, 74-80
• 6. Lu, H.-Y., Lin, M.-Y., Tsai, P.-S. and 2 more (...) (2024). Effectiveness of Cold Therapy for Pain and Anxiety Associated with Chest Tube Removal: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Pain Management Nursing, 25(1), 34-45
• 7. Nhu, N.T., Chen, D.Y.-T., Yang, Y.-C.S.H. and 2 more (...) (2024). Associations Between Brain-Gut Axis and Psychological Distress in Fibromyalgia: A Microbiota and Magnetic Resonance Imaging Study. Journal of Pain, 25(4), 934-945
• 8. Hsu, W.-C., Cheng, H.-T., Lin, C.-T. and 4 more (...) (2024). Factors affecting quality of life among patients with corrosive injury. Medicine (United States), 103(1)
• 9. Liu, I.-H., Lin, C.-J., Romadlon, D.S. and 4 more (...) (2024). Dynamic Prevalence of and Factors Associated with Fatigue Following Traumatic Brain Injury: A Systematic Review and Meta-Analysis of Observational Studies. Journal of Head Trauma Rehabilitation, 39(4), E172-E181
• 10. Liang, W., Wu, D., Chuang, Y.-H. and 2 more (...) (2024). Insomnia complaints correlated with higher risk of cognitive impairment in older adults following stroke: a National Representative Comparison Study. Sleep and Biological Rhythms, 22(1), 41-47
• 11. Palanivelu, L., Chen, Y.-Y., Chang, C.-J. and 5 more (...) (2024). Investigating brain–gut microbiota dynamics and inflammatory processes in an autistic-like rat model using MRI biomarkers during childhood and adolescence. NeuroImage, 302
• 12. Hsieh, C.C.-J., Lo, Y.-C., Wang, H.-H. and 3 more (...) (2024). Amelioration of the brain structural connectivity is accompanied with changes of gut microbiota in a tuberous sclerosis complex mouse model. Translational Psychiatry, 14(1)
• 13. Huang, Y.-Z., Chen, Y.-M., Lin, C.-C. and 2 more (...) (2024). A nursing note-aware deep neural network for predicting mortality risk after hospital discharge. International Journal of Nursing Studies, 156
• 14. Hasan, F., Muhtar, M.S., Wu, D. and 5 more (...) (2024). Web-based artificial intelligence to predict cognitive impairment following stroke: A multicenter study. Journal of Stroke and Cerebrovascular Diseases, 33(8)
• 15. Recio-Rodriguez, J.I., Fernandez-Crespo, M., Sanchez-Aguadero, N. and 7 more (...) (2024). Neurofeedback to enhance sleep quality and insomnia: a systematic review and meta-analysis of randomized clinical trials. Frontiers in Neuroscience, 18
• 16. Romadlon, D.S., Tu, Y.-K., Chen, Y.-C. and 3 more (...) (2024). Comparative Effects of Diabetes Self-Management Programs on Type 2 Diabetes Clinical Outcomes: A Systematic Review and Network Meta-Analysis. Diabetes/Metabolism Research and Reviews, 40(6)
• 17. Kuo, C.-H., Liu, G.-T., Lee, C.-E. and 7 more (...) (2024). Decoding micro-electrocorticographic signals by using explainable 3D convolutional neural network to predict finger movements. Journal of Neuroscience Methods, 411
• 18. Liao, W.-C., Cheng, Y.-Y., Hsu, C.-K. and 4 more (...) (2024). Effects of early warm water sitz bath on urinary retention and pain after haemorrhoidectomy: A randomized controlled trial. International Journal of Nursing Studies, 154
• 19. Chang, K.-M., Lin, C.-J., Jan, Y.-W. and 6 more (...) (2024). Effects of nurse-led brief behavioral treatment for insomnia in adults: a randomized controlled trial. Journal of Clinical Sleep Medicine, 20(11), 1763-1772
• 20. Hsu, H.-W., Huang, J.-P., Au, H.-K. and 7 more (...) (2024). Impact of miscarriage and termination of pregnancy on subsequent pregnancies: A longitudinal study of maternal and paternal depression, anxiety and eudaimonia. Journal of Affective Disorders, 354, 544-552
• 21. Lin, J.-H., Yu, Y.-W., Chuang, Y.-C. and 2 more (...) (2024). Correction to: ATF3-Expressing Large-Diameter Sensory Afferents at Acute Stage as Bio-Signatures of Persistent Pain Associated with Lumbar Radiculopathy (Cells, (2021), 10, 5, (992), 10.3390/cells10050992). Cells, 13(24)
• 22. Sun, C.-T., Yang, Y.-S., Lan, C.-L. and 7 more (...) (2024). Age- and gender-dependent impact of titanium vertebral augmentation implants combined with cementing on subsequent vertebral fracture incidence: A comparative study with cementing alone. European Spine Journal, 33(12), 4513-4520
• 23. Shih, C.-Y., Chiu, H.-Y. (2024). Getting to grips with early rehabilitation for the body AND mind – Response to Barghouthy et al.. Intensive and Critical Care Nursing, 83
• 24. Chen, Y.-Y., Chang, C.-J., Liang, Y.-W. and 10 more (...) (2024). Utilizing diffusion tensor imaging as an image biomarker in exploring the therapeutic efficacy of forniceal deep brain stimulation in a mice model of Alzheimer's disease. Journal of Neural Engineering, 21(5)
• 25. Yang, Y.-S., Tsou, Y.-S., Lo, W.-C. and 2 more (...) (2024). Correction to: Teriparatide Associated with Fewer Refractures and Higher Body Heights of Cemented Vertebrae after Vertebroplasty: A Matched Cohort Study (Scientific Reports, (2020), 10, 1, (6005), 10.1038/s41598-020-62869-0). Scientific Reports, 14(1)
• 26. Chang, K.-M., Romadlon, D.S., Chen, P.-Y. and 3 more (...) (2024). Effectiveness of Acupressure for Fatigue Alleviation in Patients Receiving Hemodialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Nursing Research, 32(3)
• 27. Sukarno, A., Hu, S.H.-L., Chiu, H.-Y. and 3 more (...) (2024). Factors Associated with Diabetes Self-Care Performance in Indonesians with Type 2 Diabetes: A Cross-Sectional Study. Journal of Nursing Research, 32(2)
• 28. Chen, P.-Y., Kuo, T.-M., Chen, S.-H. and 5 more (...) (2024). Psychometric properties and structural validity of traditional Chinese version of the Richards–Campbell Sleep Questionnaire in intensive care unit patients without physical restraint. Australian Critical Care, 37(4), 558-562
• 29. Chen, P.-Y., Wei, L., Su, Y.-K. and 5 more (...) (2024). Psychometric properties and factor structure of the traditional Chinese version of the Community Integration Questionnaire-Revised in traumatic brain injury survivors. International Journal of Rehabilitation Research, 47(2), 129-134
• 30. Chang, Y.-H., Lee, H.-H., Liao, Y.-S. and 6 more (...) (2024). Psychometric and structural properties of the traditional Chinese version of the sleep condition indicator for patients undergoing hemodialysis. Sleep and Breathing, 28(5), 2197-2204
• 31. Chen, T.-J., Traynor, V., Ho, M.-H. and 4 more (...) (2024). Effects of simulation-based education module on delirium care in undergraduate nursing students: A quasi-experimental study. Nurse Education in Practice, 74
• 32. Chen, S.-M., Chen, L.-Y., Lin, J.-H. and 6 more (...) (2024). Comparison of endoscopic third ventriculostomy versus cerebrospinal fluid shunt procedures for the treatment of pediatric hydrocephalus in Taiwan. Child's Nervous System, 40(9), 2883-2891